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Technology2018-09-27T07:58:59+00:00

SiBreaX is based own two core technology platforms:

  1. Stimulus responsive silicate-based nano-/microparticles for targeted compound delivery

  2. Injectable, degradable nanocomposite hydrogels for biomedical and topical applications

Overview on SiBreaX two core technology platforms:

SiBreaX Compound Delivery Platform:
Stimulus responsive carriers for compound delivery

Versatile degradable carriers for targeted compound delivery

  • Silicate-based nano-/micro particles with tunable size/shape
  • Colloidally stable in complex water solutions
  • Functionalization of particle surface for targeted delivery
  • Variable in-build “break” to trigger release and excretion

Platform for targeted compound formulation and delivery

  • Formulation/packaging of complex compounds
  • Targeted delivery via size and decoration of particle
  • Controlled release upon triggers breaking the shell (intracellular, extracellular, enzymatic activation)

SiBreaX Nanocomposite Hydrogels:
Injectable biocompatible nanocomposite hydrogels

Highly biocompatible, injectable nanocomposite hydrogels

  • Covalently linked nanoparticles in the hydrogels
  • High elasticity and mechanical stability
  • No cytotoxicity, high biocompatibility fostering cell growth
  • Fast reaction times (gelation) at mild (in vivo) conditions

Numerous medical, topical and life sciences applications

  • In situ gelation of matrices for surgeries
  • In vivo applications for wound healing and closure
  • Topical applications for cosmetics
  • Cell growth in matrix for life sciences applications

Compound delivery based on mesoporous silicate-based particles

Mesoporous silicate-based particles and their …

Mesoporous silicate-based nano-/microparticles with in-build release-trigger …

… for controlled release of cargo at the target site and degradation for excretion

… superior properties for delivery

Versatile, tunable, stable particles

  • Tunable sizes and pore sizes (20 nm – 10 µm)
  • Colloidally stable in complex aqueous solutions (long shelf life)
  • High load factor

Complex compound formulation, targeted delivery and controlled release

  • Non-covalent incorporation of most types of compounds (hydrophilic & hydrophobic small molecules, RNA, peptides, etc.)
  • Functionalization of the shell surface with tags to guide tissue/cell targeting
  • Various inbuild „breaks“ for triggered release (redox, enzymatic, etc.)

High biocompatibility for in-vivo use

  • No cytotoxicity
  • High cellular uptake and cargo release
  • Efficient degradation into small particles for simple excretion to avoid accumulation

Compound delivery based on hard shell silicate-based particles

Hard shell silicate-based capsules and their …

Hard shell silicate-based capsules with in-build release-trigger …

… for controlled release of cargo at the target site and degradation for excretion

… superior properties for delivery

Versatile, tunable, stable capsules

  • Tunable sizes (40-60 nm)
  • Colloidally stable in complex aqueous solutions (long shelf life)
  • Full protection of cargo from solution

Complex compound formulation, targeted delivery and controlled release

  • Non-covalent incorporation of most types of compounds (hydrophilic & hydrophobic small molecules, proteins, peptides, etc.)
  • Functionalization of the shell surface with tags to guide tissue/cell targeting
  • Various inbuild „breaks“ for triggered release (redox, enzymatic, etc.)

High biocompatibility for in-vivo use

  • No cytotoxicity
  • Efficient cellular uptake and cargo release
  • Efficient degradation into small particles for simple excretion to avoid accumulation

Vertasile nanocomposite hydrogels for biomedical applications

Injectable nanocomposite hydrogels with …

Injectable nanocomposite hydrogels with covalently linked nanoparticles

… for superior biocompatibility within biomedical/life sciences applications

Cell growth within hydrogel

Cell growth at tissue-hydrogel boarder

Fast, in situ gelation for easy application

… superior properties for in vivo use

  • Nanocomposite hydrogels with covalently linked, degradable silicate-based nanoparticles as structural component
    – High mechanical stability
    – High elasticity
    – Transparent
  • High biocompatibility fostering cell growth
    – No cytotoxicity
    – Very low disturbance (e.g., inflammation)
    of cells at gel-tissue boarder
    – High water content
    – Large pore sizes enabling cell infusion
    – Degradable material for excretion
  • Simple application with in situ gelation
    – Very fast, mild reaction conditions
    (in vivo)
    – Self-healing